American Cancer Society

The American Cancer Society Discovery Shop in Laguna Niguel offers a unique thrift shopping experience where every purchase supports vital cancer research and patient services. Located at 27281 La Paz Rd Suite E, this well-organized boutique-style thrift store has become a beloved destination for savvy shoppers throughout Southern California's Orange County. Unlike typical thrift stores, the American Cancer Society location in Laguna Niguel curates high-quality donated items, creating a pleasant shopping environment that feels more like browsing a upscale consignment shop than a traditional secondhand store. The friendly volunteer staff are passionate about the mission, and shoppers appreciate knowing their bargain finds directly fund cancer research, patient support programs, and community health initiatives. Whether you're hunting for designer labels at thrift store prices or simply want to support a worthy cause while updating your wardrobe, this Laguna Niguel gem delivers both value and purpose.

Store Information

27281 La Paz Rd ste e, Laguna Niguel, CA 92677

Phone: +1 800-227-2345

Website: https://www.cancer.org/

3.8★ average across 26 reviews on Google

Store Hours

  • Monday: Closed
  • Tuesday: 10AM-5PM
  • Wednesday: 10AM-5PM
  • Thursday: 10AM-5PM
  • Friday: 10AM-5PM
  • Saturday: 10AM-5PM
  • Sunday: 12-4PM

What They Sell

The American Cancer Society Discovery Shop in Laguna Niguel specializes in gently-used clothing, accessories, home décor, and household items donated by community members. Shoppers frequently discover designer clothing labels, vintage jewelry, current fashion trends, and quality home furnishings at fraction-of-retail prices. The store's South Orange County location means the donation pool often includes upscale brands and well-maintained items from nearby affluent communities. You'll find everything from professional workwear and casual clothing to decorative accessories, small furniture pieces, books, and seasonal items, with inventory constantly rotating based on community donations.

The Neighborhood

Nestled in the heart of Laguna Niguel, California, this shop enjoys a prime location along La Paz Road, one of the area's main commercial corridors. The surrounding neighborhood features a mix of shopping plazas, professional offices, and residential communities, making it easily accessible for locals and visitors from nearby Laguna Hills, Mission Viejo, and Dana Point. The area's affluent South Orange County demographics mean shoppers often discover surprisingly upscale donations, and the convenient location near the 73 Toll Road makes it a perfect stop during errands.

Parking

Parking at this La Paz Road location is convenient and hassle-free, with ample free parking available in the shopping plaza lot directly in front of the store. The strip mall setting provides easy access with designated spaces, and shoppers rarely encounter parking difficulties even during peak weekend hours. The flat, accessible lot makes it simple to load larger purchases into your vehicle.

Shopping Tips

  • Visit on Tuesday or Wednesday mornings right after opening to see newly processed donations before they're picked over.
  • Ask volunteers about upcoming special sales or discount days when the store offers additional markdowns on select items.
  • Bring cash for smaller purchases, though most Discovery Shops accept cards—confirm payment options when you arrive.
  • Check back frequently since inventory changes daily based on community donations, and that designer piece you've been wanting might appear any day.
  • Don't hesitate to chat with volunteers about the store's mission; many have personal connections to cancer causes and appreciate engaged shoppers who support their work.

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